In nature, very sweet foods signal high calorie content to the body which readies itself in response to the food intake.
Responding to the study, published in the journal Current Biology, Tam Fry, of the National Obesity Forum, said: "This research should be enough to convince you that artificial ingredients, whether they be in food or drink, can screw up your system even though they may sound healthy".
"The assumption that more calories trigger greater metabolic and brain response is wrong".
The response explains the association between artificial sweeteners and diabetes discovered in earlier studies.
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When we go on a diet, we often add artificially sweetened drinks and low-calorie dishes to help us meet our goal, but we may be tricking our metabolism into piling on even more weight and triggering diabetes, says a new study from Yale University.
Dana Small, Professor at Yale University, "A calorie is not a calorie".
The body has been designed in a way to consume more calories when something sweet is pushed in it.
When a drink is too sweet for the calories it contains, the brain becomes confused, Expressdigest.com reported. These sweeteners might lack calories, but not consequences, of which, diabetes is only one. "Either may affect metabolic health".
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British experts, who are unconvinced about the study, are of the opinion that people who are concerned about taking diet drinks should stick to drinking water.
When a "mismatch" occurs, the brain's reward circuits don't register that calories have been consumed, the researchers said.
According to her, human bodies are evolved to use the available natural sources of energy efficiently, but, the modern food environment consists of energy sources that are not seen by the bodies before.
"The statement that a calorie is not a calorie is gobbledegook", said Tom Sanders, Professor emeritus of Nutrition and Dietetics, at King's College London.
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