It has been working to develop a nuclear-tipped missile capable of striking the USA mainland, and experts say its test on Sunday of a new missile was another important step toward that aim.
His comments come amid growing tensions between the United States and the rogue nation - over its nuclear program.
President Donald Trump issued another strong warning to North Korea Friday.
But he stressed the USA is pursuing "a very determined diplomatic effort" led by Secretary of State Rex Tillerson that is coupled with new financial sanctions to dissuade North Korean leader Kim Jong Un from further provocations. "It is probably fair to say they are moving toward that at an ever-alarming rate", he said when asked whether North Korea has nuclear weapons capable of hitting the U.S.
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"I will not be surprised that they will do another missile test. We've engaged the world to support that policy", Pompeo said, adding there will no longer be "strategic patience", the policy of former President Barack Obama, which centered on waiting for Pyongyang to return to denuclearization talks while increasing sanctions and pressure on the regime.
The United States, which has 28,500 troops in South Korea to guard against the North Korean threat, has called on China to do more to rein in its neighbor.
Pompeo also said that the problem has been ongoing through previous USA administrations, but he argued President Donald Trump was making strides to effect change.
Referring to Kim, President Trump added: "If he utters one threat ... or if he does anything with respect to Guam or any place else that's an American territory or an American ally, he will truly regret it, and he will regret it fast".
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"I've seen no intelligence to indicate we're in that place today", Pompeo said.
Several countries have expressed concern with the escalation of the crisis.
The Washington Post reported this week that the US Defense Intelligence Agency has concluded that North Korea has developed a miniaturised nuclear warhead that could be put atop an ICBM.
In an interview with German newspaper group RND, Gabriel said the maneuvers "could lead to North Korea using the opportunity for renewed provocation, for example, by firing an intermediate-range missile at Guam".
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In response, Mr Trump said North Korea should expect "big, big trouble" if anything happened to Guam.