Chelsea midfielder N'Golo Kante has reportedly been ruled out for the rest of October 2017 following the injury the Frenchman sustained while on global duty.
Saturday's Premier League clash with bottom-of-the-table Palace should present few problems despite the absence of Kante, but the European clashes against in-form Roma could prove a greater challenge without the former Leicester City player's influence.
The health of Kante and Alvaro Morata is sure to be on the agenda at Friday's pre-match media conference. Sadio Mane returned to Liverpool with a hamstring issue sustained while in action with Senegal, while Arsenal boss Arsene Wenger this morning confirmed that Shkodran Mustafi is sidelined for six weeks with a thigh issue picked up with the Germany national team.
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It is more realistic that, if fit, Morata will be kept in reserve for next Wednesday's Champions League tie at home to Roma, where the Blues will be seeking a third win from three Group C games.
There could be good news for Chelsea, too.
Whether it comes at Palace or against Roma remains to be seen.
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Fortunately for Conte, he has strength in depth in the middle of the park following Danny Drinkwater's deadline day capture, though the England global is yet to feature for his new side on the back of his switch to Stamford Bridge. It was their second defeat of the season following the opening-day defeat to Burnley.
The Blues are scheduled to play half-a-dozen matches during the rest of October, with Manchester United to follow at Stamford Bridge on the first weekend in November.
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