The Reds forward suffered a hamstring injury while away on worldwide duty this week.
That's a huge blow for the Reds ahead of their home meeting with Manchester United this Saturday afternoon - but they should have enough firepower to cope in his absence.
He has already missed three domestic matches this season after receiving a suspension following his sending off at Manchester City last month.
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It was during that run of fixtures that concerns over Liverpool's accuracy in front of goal came into sharp focus - Jurgen Klopp's side had 79 shots in the games he missed, just 18 of which were on target.
The 25-year-old's importance to Liverpool going forward is unquestioned.
That is according to former Premier League star David Ginola.
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Since the start of last season with Mane in the team, they have won 19 of 32 Premier League games and averaged 2.2 goals and 2.1 points per match in the process.
Sportsmail looks at three different ways that Klopp's Liverpool could line up without their key player. Ahead of the 3-3 draw at Watford on the first day of the season, he said of playing Mane and Salah together: 'It makes us more hard to defend because speed is the most hard thing to defend in football.
"Liverpool especially we talk a lot about (Philippe) Coutinho, Sadio Mane is another one".
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