The midfielder, suspended for the derby this weekend after a red card at Arsenal, is planning on being heavily involved in the build-up and on the sidelines.
"We need points and we need to win".
The Manchester United boss will be without the France global for the crunch title clash against Pep Guardiola's Manchester City, with Mourinho hoping to reduce the eight-point deficit at the top of the Premier League in his absence.
Serie A top four all draw blanks
Napoli missed the chance to move top of the Serie A table after they were held to a 0-0 draw by Fiorentina on Sunday afternoon. AC Milan returned to winning ways in the Italian top flight with a 2-1 victory over Bologna on Sunday evening.
Mourinho is aware of the significance of Pogba's suspension and revealed what aspect of his game sets him apart from every other Man United midfielder.
'We have lost a very important player, one with an impact in the way we play and that is obvious, ' Mourinho said. Manchester United are tailor-made to get a result against City. He impacts our style.
'Kill the game when you have one chance because they have quality as well in front and they can kill the game at any time. Fellaini can score an incredible header. It's not pessimistic. It's just a different way to play football.
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"But a midfield player to do and create what he [Pogba] did in the third goal [against Arsenal], as an example, we don't have". Matic can shoot from outside the box.
During his pre-match press conference on Friday, the United boss admitted there's nobody else like Pogba in his squad, referencing the Frenchman's excellent assist when he used his strength to shrug off compatriot Laurent Koscielny and crossed for Jesse Lingard to convert the clinching third goal against Arsenal.
Mourinho is expected to replace his talisman with Ander Herrera, who has started 10 of the 15 Premier League games on the bench.
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'It's going to be a big atmosphere in the stadium and a big game with a big team and big players so that's the game you want to play.