The minister said the launch of the oral cholera vaccination on Wednesday was another move to accelerate the fight to the epidemic.
Dr Nathan Bakyaita Zambia's World Health Organization representative said that enough vaccine to treat one million people has been delivered to the southern African country.
Security forces fired teargas to disperse protesters who burned tires in the Lusaka neighborhood of Kanyama, where authorities closed businesses to try to curb the spread of the disease, police spokeswoman Esther Katongo said by text message.
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"Cholera is spread through dirty water and poor sanitation as well as contaminated food".
Zambia's capital, Lusaka, has been the worst hit with cholera which causes acute diarrhoea and can kill within hours if left untreated.
The Zambian government said Thursday that its interventions to tackle a cholera outbreak have started bearing fruits with marked reduction of new cases in the last two days.
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"We have continued to report marked reduction in the number of new cases and this is good", Chilufya said.
According to the ministry, cases in the capital cumulatively now stand at 2,755 out of which 2,514 have been successfully treated and discharged.
The cumulative death toll in the city now stands at 62, while the countrywide death toll stands at 67.
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The cholera outbreak was initially ascribed to contaminated water from shallow wells, but investigations suggest that contaminated food may also be to blame.