Aguero now trails Harry Kane by just two goals in the race for the golden boot, but just one from Kane was enough to win the North London derby as the Tottenham striker's seventh goal in as many games against Arsenal secured a 1-0 win.
Since August 2012, when De Bruyne joined Werder Bremen, he has provided 77 assists in Europe's top five leagues.
'No doubt, ' came the reply.
But as impressive as the Argentinian was, City again owed a lot to the irrepressible De Bruyne, who created his side's opening three goals in another outstanding display.
With his handful of goals yesterday, it meant that Aguero has now scored at least 20 league goals in each of the past four Premier League seasons, undoubtedly signalling him as one of the best to have graced English football. Every three games. He knows - and everyone knows - to be there, you have to win titles, and titles and titles. 'You have to be there in the latter stages. "Without getting to the latter stages, you will not be nominated".
"I do everything to win titles with the team", the Belgian said. "What happens after is an extra", he told reporters.
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'I'm very pleased with the way everything is going for me.
"He is a great player and any team in the world would love to have him". It makes it easier for me; it makes it easier for them. "At the end, if you get an individual honour it is attractive", he added.
Otamendi drew another save from Schmeichel, but the Leicester keeper was at fault for City's fourth when he gave the ball straight at Aguero when trying to play out from the back, allowing the Argentine to lift his finish over the stranded shot-stopper and into the empty net for his hat-trick.
Kevin De Bruyne is not just the most creative player in the Premier League, but also one of the complete midfielders around. 'If he is on it, he is probably the best for me.
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De Bruyne has scored 11 goals and provided 18 assists across all competitions for Manchester City this season, helping them establish a 16-point lead atop the league table.
It all rendered the appearance of Riyad Mahrez at the Etihad rather irrelevant just 10 days after his proposed move from Leicester to City fell through before the transfer window closed.
But in a boost to City fans, Pep said: "Gabriel is coming back soon". 'It was a hard situation to manage.
"The deal is not to look forward but try to get into the quarter-finals for a second time and go through - what we were not able to do last season".
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"If this man does not win Footballer of the Year then there is something very wrong with the way we reward our best players".