At least one person has reportedly been shot and wounded and one suspect taken into custody at the US National Security Agency's headquarters.
He did confirm that one person had been injured and transported, although he did not say where the person had been transported to.
The incident, which happened shortly after 7 a.m. ET, is not terror-related, USA officials told CNN.
Aerial footage showed the SUV stopped at the gate.
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"The situation is under control and there is no ongoing security or safety threat", the NSA said in a statement.
"Our thoughts and prayers are with everyone that has been affected", a White House statement said.
A law enforcement source said the FBI's Baltimore office was handling the investigation but it was "too soon to tell" whether it was an attack.
The Fort Meade base is located roughly 30 miles northeast of the White House.
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Nearby, a black SUV with bullet holes through its windshield appeared to have crashed into a concrete barrier at one of the facility's secure vehicle entry gates.
The shooting occurred just after 7 a.m. when a vehicle attempted to enter the agency's secure campus near Fort Meade without authorization and weapons were fired.
Local radio station WBAL first reported that three people had been struck by bullets. Most motorists then carefully follow the orders of heavily armed federal officers and turn around without getting into more trouble. The investigation into the attack is now underway. Authorities later said they had stolen a vehicle from a man who picked them up for a party at a motel.
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