The Labour mayor is the first British politician to give a keynote speech at the South by Southwest conference in Texas.
London mayor Sadiq Khan is set to call for sweeping regulatory changes today in order to stop large, multinational tech companies from thinking they are "above the law". "One of the biggest problems over the last few years is that politicians and governments have just been passive - sitting on their hands - while the tech revolution has happened around them".
"There's been a dereliction of duty on the part of politicians and policy-makers to ensure that the rapid growth in technology is utilised and steered in a direction that benefits us all", he will tell crowds.
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As well as this, Khan will read out examples of the abusive and illegal tweets that he has received since he became mayor. "I know this all too well from personal experience", he will say.
"What we need to see is a stronger duty of care so that social media platforms can live up to their promise to be places that connect, unify and democratise the sharing of information - and be places where everyone feels welcome and valued", Khan continued. But this is not always happening, or happening quickly enough.
Hate speech and fake news have been rife on social media, with Twitter revealing Russian bots retweeted Donald Trump tweets 500,000 times in the run up to the USA election, while the government has considered imposing a levy on tech giants in a bid to combat online abuse. I welcome this. But - with the skills and resources these companies have at their disposal - I believe it's possible to go further and faster.
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"There's been a failure to ensure that our economies and our regulatory structures are prepared and relevant", Khan will add.
Khan will also warn Uber and other tech firms that all companies "must play by the rules" in the markets in which they operate. "Evolving economies must mean evolving regulation".
Polgreen, who runs HuffPost in the United States, will then spend time with Khan discussing some of the key themes from his speech, and take questions from the audience in the auditorium and online.
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