And on the eve of the 2018 marathon, the mayor believes the tragedy has united the city.
Hasay, New York City Marathon victor Shalane Flanagan and fellow Americans Desiree Linden and Molly Huddle had been expected to challenge Kenyan defending champion Edna Kiplagat to end the nation's 33-year wait for a home victor in the women's race.
General view of the pack of elite women near the start of the 2017 Boston Marathon. The Nike-sponsored runner lost by 21 seconds to Kenya's Geoffrey Kirui a year ago and hopes to come out on top the second time around.
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Among the thousands of racers who will lace up their sneakers on Monday, marking five years since the terrorist bombing, Shalane Flanagan is one to watch out for. Rupp took a bronze medal at the 2016 Rio Olympics then followed his Boston debut runner-up effort with a Chicago victory.
The run will be noticeably different for him this year.
Although Huddle's time in her marathon debut was on 2:28:13 she has the competitive temperament to make her second attempt at the distance even more memorable.
Both gathered momentum from Boston, with Kirui going on to take the world title in London and his American opponent, the London 2012 10,000m silver medallist, earning a first marathon win in Chicago.
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Meanwhile, Kirui aims to repeat last year's success.
More recently Rupp has become only the second USA runner to break the hour mark for the half-marathon.
Jordan Hasay, who set records at the 2017 Boston Marathon, announced on Twitter on Sunday that she has withdrawn from this year's race.
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